In the field of research, Sts Cyril and Methodius Faculty of Theology of Palacký University (CMTF), through the Centre for Patristic, Medieval and Renaissance Texts, focuses on the extensive field of study of patristic (Greek and Latin), medieval and Renaissance texts, with a specific orientation on texts related to the Czech lands. This center is a unique scientific workplace within the Czech Republic. Research activities in the field of biblical studies are currently involved in the Centre of Excellence for the History and Interpretation of the Bible.

Through the Institute of Social Health (OUSHI), CMTF UP focuses on scientific research and education in the field of health, with special emphasis on social and spiritual determinants of health. It takes into account a holistic view and uses a bio-psycho-socio-spiritual model of health.

The Institute of Intercultural, Interreligious and Ecumenical Research and Dialogue (IIMEVD), whose core mission is to strengthen basic research at Sts Cyril and Methodius Faculty of Theology at UP, was established as an excellent research faculty in December 2014. It culminated fifteen years of research and teaching work of the Department of Pastoral and Spiritual Theology, whose research team, under the leadership of Professor Pavel Ambros, has long been working on the relationship between faith, culture and spirituality in different Christian traditions and religions.

Through its individual departments, CMTF UP also focuses on the most important professional theological texts (participation in the translation of the Bible, the outstanding works of some medieval theologians, the compilation and making available of Czech translations of important church documents in the field of systematic theology from the 20^th century and the contemporary ones, translations of liturgical and legal texts), expert work on sections of church history with a focus on Czech lands, including allowing access to important archival materials and addressing current issues related to religion, interreligious and intercultural dialogue, dialogue between science and religion, and the work of Christians in the charitable, social and pedagogical spheres.

This research activity is largely the subject of various grant projects.